for Veterans and the Public
This class of anti-HIV drugs works by blocking an enzyme (HIV integrase) that the virus needs in order to splice copies of itself into human DNA.
- Isentress® (raltegravir)
- Tivicay® (dolutegravir)
- Vitekta® (elvitegravir)
(Note: Vitekta must be "boosted" with a pharmacokinetic enhancer, either Tybost® or Norvir®.)
Some integrase inhibitors are combined with NRTIs in fixed-dose combination tablets. (See multi-class drug combinations)