for Veterans and the Public
Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs or non-nukes)
The second type of antiretroviral drugs is the non-nucleoside reverse transcriptase inhibitors (NNRTIs). These drugs are sometimes called non-nucleosides or "non-nukes."
These drugs also prevent HIV from using reverse transcriptase to make copies of itself, but in a different way.
These NNRTIs are currently in use. The are two older NNRTIs that currently are not used in the United States; for more information, see the Drug Dosing Toolkit.
- Efavirenz (brand name: Sustiva®)
- Etravirine (brand name: Intelence®)
- Rilpivirine (brand name: Edurant®)
Some NNRTIs are combined with NRTIs in fixed-dose combination tablets. (See multi-class drug combinations, below.)