Attention A T users. To access the menus on this page please perform the following steps. 1. Please switch auto forms mode to off. 2. Hit enter to expand a main menu option (Health, Benefits, etc). 3. To enter and activate the submenu links, hit the down arrow. You will now be able to tab or arrow up or down through the submenu options to access/activate the submenu links.



Quick Links

Veterans Crisis Line Badge
My healthevet badge
EBenefits Badge

Non-nucleoside reverse transcriptase inhibitors (NNRTIs or 'non-nukes')

for Veterans and the Public

Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs or non-nukes)

The second type of antiretroviral drugs is the non-nucleoside reverse transcriptase inhibitors (NNRTIs). These drugs are sometimes called non-nucleosides or "non-nukes."

These drugs also prevent HIV from using reverse transcriptase to make copies of itself, but in a different way.

These NNRTIs are currently in use. The are two older NNRTIs that currently are not used in the United States; for more information, see the Drug Dosing Toolkit.

  • Efavirenz (brand name: Sustiva®)
  • Etravirine (brand name: Intelence®)
  • Rilpivirine (brand name: Edurant®)

Some NNRTIs are combined with NRTIs in fixed-dose combination tablets. (See multi-class drug combinations, below.)