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HIV

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Nucleoside reverse transcriptase inhibitors (NRTIs or 'nukes')

for Veterans and the Public

Nucleoside Reverse Transcriptase Inhibitors (nucleoside analogues, NRTIs or nukes)

Treatment

When the HIV virus enters a healthy cell, it attempts to make copies of itself. It does this by using an enzyme called reverse transcriptase. The NRTIs work because they block that enzyme. Without reverse transcriptase, HIV can't make new virus copies of itself.

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