Table 1. Potential ARV Interactions

Methadone:

• The following may ↓ methadone levels. Monitor for signs of opiate withdrawal. Dosage adjustment of methadone may be needed.
  • NRTIs: ABC
  • NNRTIs: EFV, NVP
  • PIs: ATV, DRV, FPV/r, LPV/r, NFV, SQV/r, TPV/r
• DLV may ↑ methadone levels. Start methadone at low dosage, monitor for methadone toxicity.
• Methadone may ↓ ddI levels. Dosage adjustment not established.

Buprenorphine:

• PIs: May ↑ buprenorphine levels and ↑ risk of adverse effects.
• EFV: May ↓ buprenorphine levels; monitor for signs of opiate withdrawal.
• Dosage adjustment of buprenorphine may be needed.