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Drug Dosing Toolkit: Isentress (Raltegravir)

for Veterans and the Public

Isentress (raltegravir)

Type of Drug: Integrase Inhibitor
This is the first approved drug in a class of drugs called integrase inhibitors. It works by blocking an enzyme that the virus needs in order to make more virus. The enzyme that it blocks is called HIV integrase.

one 400 mg capsule Isentress two times a day

  • Morning
    Isentress 400mg


  • Evening
    Isentress 400mg


Notes on taking this medication

  • Isentress interacts with certain tuberculosis medication. If you're being treated for TB or MAC, let your HIV provider know.

Side effects

  • Usually well tolerated; may cause nausea; diarrhea; headache; muscle aches; rash
  • Contact your doctor promptly if you experience unexplained muscle pain, tenderness, or weakness

See accompanying chart: Tips for Common Side Effects


Disclaimer: This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.