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Drug Dosing Toolkit: Atripla

for Veterans and the Public

Atripla (Sustiva + Viread + Emtriva)

Type of Drug: Fixed-Dose Combination
Fixed-dose combinations combine the most commonly prescribed doses of several medications into 1 pill.

Approved adult dosing

Sustiva 600 mg + Viread 300 mg + Emtriva 200 mg in a single tablet

one tablet Atripla at bedtime

  • Daily


Notes on taking this medication

  • Take at bedtime
  • Take on an empty stomach
  • Sustiva component interacts with many other drugs; consult your medical provider
  • Persons with kidney problems may need an adjustment to their doses of the component drugs, and have to take them separately, not as a single pill

Same side effects as


  • Sleep disturbances such as vivid dreams (improves over the first several weeks); dizziness; drowsiness; mood disturbances
  • Difficulty with concentration
  • Rash
  • Do not take during first trimester of pregnancy or if you may become pregnant while taking it; may cause birth defects


  • Gassiness; abdominal discomfort; nausea; diarrhea
  • Kidney impairment
  • Viread is active against hepatitis B, and stopping it can cause "flare-up" of hepatitis B


  • Skin discoloration (particularly in dark-skinned people)
  • Emtriva is active against hepatitis B, and stopping it can cause "flare-up" of hepatitis B

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

Disclaimer: This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.