Attention A T users. To access the menus on this page please perform the following steps. 1. Please switch auto forms mode to off. 2. Hit enter to expand a main menu option (Health, Benefits, etc). 3. To enter and activate the submenu links, hit the down arrow. You will now be able to tab or arrow up or down through the submenu options to access/activate the submenu links.



Quick Links

Veterans Crisis Line Badge
My healthevet badge
EBenefits Badge

TDF/FTC Lowers Lipids

for Health Care Providers

Switch to TDF/FTC from ABC/3TC Lowers Lipids

Are you still conflicted about the choice between the NRTI backbones abacavir/lamivudine (ABC/3TC) and tenofovir/emtricitabine (TDF/FTC)? A recent report will give you more to consider. It has been observed in other studies that patients on TDF/FTC tended to have lower lipid values than those on ABC/3TC. This randomized open label switch study of hyperlipidemic (TC >200 mg/dL) patients (n = 157) on stable suppressive ABC/3TC + efavirenz explored that issue. Half switched to TDF/FTC/EFV (fixed-dose combination). After 12 weeks, the remaining ABC/3TC patients also switched. At week 12, all lipid measures had decreased in the switch group but not in the control group: total cholesterol dropped 33 mg/dL, LDL and triglycerides dropped 17-18 mg/dL, and HDL dropped 6 mg/dL. At week 24, similar changes were seen in the remaining patients switched to TDF/FTC. Authors report no changes in eGFR and no differences between groups in rates of proteinuria.


Moyle GJ, Orkin C, Fisher M, et al. A randomized comparative trial of continued abacavir/lamivudine plus efavirenz or replacement with efavirenz/emtricitabine/tenofovir DF in hypercholesterolemic HIV-1 infected individuals. PLoS One. 2015 Feb 6;10(2):e0116297.