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PrEP and HCV

for Health Care Providers

HIV PrEP and Incident HCV Infection

Providers at Kaiser San Francisco, which has a large HIV preexposure prophylaxis (PrEP) program, recently published a brief report on 2 patients who developed acute HCV while on HIV PrEP. This reinforces what we might expect--that while PrEP may be effective as an HIV prevention method, its use may be associated with increased risks for other sexually transmitted diseases (STDs), including HCV. It is a reminder of the importance of ongoing STD risk reduction counseling for persons on PrEP.


Volk JE, Marcus JL, Phengrasamy P, et al. Incident hepatitis C virus infections among users of HIV preexposure prophylaxis in a clinical practice setting. Clin Infect Dis. Published online February 18, 2015. doi:10.1093/cid/civ129