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Drug Dosing Toolkit: Aptivus

for Veterans and the Public


Type of Drug: Integrase Inhibitor
Integrase inhibitors work by blocking an enzyme (HIV integrase) that the virus needs in order to make more virus.

Bring a printout of this page to discuss with your doctor during your next visit. List your questions at the bottom of the page.

Approved adult dosing

See elvitegravir + cobicistat + tenofovir alafenamide + emtricitabine (Genvoya) and elvitegravir + cobicistat + tenofovir DF + emtricitabine (Stribild).

* Elvitegravir is only available in coformulation (see Genvoya, Stribild).

Notes on taking this medication

  • Take with food
  • Antacids, laxatives, mineral supplements, and other compounds that contain calcium, magnesium, aluminum, or iron can decrease levels of elvitegravir if they are taken close in time to each other. Ask your provider whether or how you can take these compounds with elvitegravir.
  • Elvitegravir must be taken with a pharmacokinetic enhhancer. It currently is only available in coformulations that also include the pharmacokinetic enhancer cobicistat.

Possible side effects

  • Elvitegravir has not been studied during pregnancy; tell your medical provider if you become pregnant while taking this drug
  • Diarrhea, headache
  • Rash

See accompanying chart: Tips for Common Side Effects


Disclaimer: This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.