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Drug Dosing Toolkit: Videx EC

for Veterans and the Public

didanosine, ddI EC (Videx EC)

Type of Drug: Nucleoside Reverse Transcriptase Inhibitor

Nucleoside reverse transcriptase inhibitors were the first type of drug available to treat HIV. They are also known as NRTIs, nucleoside analogues, or "nukes."

When the HIV virus enters a healthy cell, it attempts to make copies of itself. It does this by using an enzyme called reverse transcriptase. NRTIs block that enzyme, so HIV cannot make new copies of itself.

Bring a printout of this page to discuss with your doctor during your next visit. List your questions at the bottom of the page.

Approved adult dosing

one 400 mg capsule Videx EC once a day

  • Daily
    Videx EC 400mg

    Videx EC 400 mg

If under 133 pounds:

one 250 mg capsule Videx EC once a day

  • Daily
    Videx EC 250mg

    Videx EC 250 mg

Note: Generic formulations are available; these generic pills may have different shapes and colors than the ones shown above.

Notes on taking this medication

  • Videx EC is no longer recommended for treatment of adults with HIV; if you are taking Videx EC, please talk with your clinician about changing to a different medication
  • Dose may need to be adjusted because Videx EC can interact with other HIV drugs; dose should be reduced to 250 mg once a day if taken with Viread, Truvada, or Atripla
  • Take on empty stomach 2 hours after or 1 hour before meal (if taken with Viread, there are no food restrictions)
  • Persons with kidney problems may need an adjustment to their dose of Videx EC

Possible side effects

  • Numbness, tingling, or pain in the hands and feet (peripheral neuropathy)
  • Nausea; vomiting; diarrhea; abdominal pain
  • Pancreatitis
  • Changes in body-fat distribution, especially fat loss

See accompanying chart: Tips for Common Side Effects


Disclaimer: This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.