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Drug Dosing Toolkit: Tybost

for Veterans and the Public

cobicistat (Tybost)

Type of Drug: Pharmacokinetic Enhancer

A pharmacokinetic enhancer "boosts" certain other drugs by increasing their levels in the body and slowing their elimination.

Bring a printout of this page to discuss with your doctor during your next visit. List your questions at the bottom of the page.

Approved adult dosing

150 mg tablet Tybost

  • Daily


Notes on taking this medication

  • Used as a booster of the integrase inhibitor elvitegravir and of certain protease inhibitors; must be taken with one of these
  • Should take with food
  • Tybost interacts with many other drugs; persons using Tybost with those drugs may need an adjustment to their dose of Tybost or the other drugs; consult your medical provider

Possible side effects

  • Nausea, diarrhea
  • Headache
  • Fatigue
  • Elevation in blood creatinine levels (this is used to assess kidney function; your provider will monitor creatinine)

See accompanying chart: Tips for Common Side Effects


Disclaimer: This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.