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Drug Dosing Toolkit: Crixivan

for Veterans and the Public

Crixivan (indinavir)

Type of Drug: Protease Inhibitor
Once HIV has infected a cell and made copies of itself, it uses an enzyme called protease to process itself correctly so it can be released from the cell to infect other cells. Protease inhibitors work by blocking that enzyme.

Bring a printout of this page to discuss with your doctor during your next visit. List your questions at the bottom of the page.

Approved adult dosing

two 400 mg capsules Crixivan + one 100 mg tablet ritonavir (Norvir) two times a day

  • Morning
    Crixivan 400mgCrixivan 400mg

    indinavir (Crixivan)

    +
    Norvir 100mg

    ritonavir (Norvir)

  • Evening
    Crixivan 400mgCrixivan 400mg

    indinavir (Crixivan)

    +
    Norvir 100mg

    ritonavir (Norvir)

Notes on taking this medication

  • Because of the possibility of severe side effects, indinavir (Crixivan) is not recommended for treatment of HIV; if you are taking indinavir, please talk with your health care provider about changing to a different medication
  • Drink 6-8 glasses of water per day to reduce risk of kidney stones
  • Crixivan interacts with many other drugs; persons using Crixivan with those drugs may need an adjustment to their dose of Crixivan or the other drugs; consult your medical provider

Side effects

  • Kidney stones; flank or back pain
  • Nausea; vomiting; diarrhea; headache
  • Abnormal accumulation of body fat
  • Increased blood sugar
  • Elevations in cholesterol and triglycerides
  • Liver inflammation and increased liver enzyme levels
  • Hair loss; dry skin; ingrown nails
  • Jaundice (yellowing of the eyes or skin)

See accompanying chart: Tips for Common Side Effects

Notes

Disclaimer: This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.