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Drug Dosing Toolkit: Combivir

for Veterans and the Public

AZT + lamivudine (Combivir)

Type of Drug: Fixed-Dose Combination
Fixed-dose combinations include several medications in 1 pill.

Bring a printout of this page to discuss with your doctor during your next visit. List your questions at the bottom of the page.

Approved adult dosing

AZT 300 mg + lamivudine (3TC, Epivir) 150 mg in a single tablet

one tablet Combivir two times a day

  • Morning


  • Evening


Note: Generic formulations are available; these generic pills may have different shapes and colors than the one shown above.

Notes on taking this medication

  • Because of the possibility of serious side effects from AZT, this combination is not generally recommended for treatment of HIV; if you are taking AZT + lamivudine (eg, Combivir), talk with your clinician about changing to a different medication
  • No food restrictions, can take with or without food
  • Persons with kidney problems may need an adjustment to their doses of the component drugs, so may not be able to take this combination pill

Same possible side effects as

AZT (Retrovir)

  • Nausea; stomach discomfort; headache
  • Symptoms of anemia (low red blood cell count): fatigue; shortness of breath
  • More rarely: muscle wasting; neutropenia (low white blood cell count)
  • Changes in body-fat distribution

Lamivudine (3TC, Epivir)

  • Side effects are rare but include headaches and general sense of feeling ill
  • Lamivudine is active against hepatitis B, and stopping it can cause "flare-up" of hepatitis B

See accompanying chart: Tips for Common Side Effects


Disclaimer: This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.