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Biochemical Features of Liver Disease and Common Causes

for Health Care Providers

Biochemical Features of Liver Disease and Common Causes

Back to Liver Disease and Cirrhosis Chapter

Elevated aminotransferases (AST, ALT)Elevated alkaline phosphatase (with or without bilirubin elevation)Elevated bilirubin (without increase in alkaline phosphatase)
(See web-based course on liver function test abnormalitiesLink will take you to our Viral Hepatitis internet site.)
  • Chronic HCV
  • Chronic HBV
  • Autoimmune hepatitis
  • Nonalcoholic steatohepatitis (NASH)
  • Drug effect/hepatotoxicity
  • Alcohol
  • Primary biliary cirrhosis
  • Sclerosing cholangitis
  • Drug-induced liver injury
  • Infiltrative liver disease
  • Sarcoidosis
  • Granulomatous hepatitis
  • Cirrhosis
  • Drug effect (eg, ATV and IDV commonly cause isolated elevation of unconjugated bilirubin)

From Liver Disease and Cirrhosis
Primary Care of Veterans with HIV
Office of Clinical Public Health Programs
Veterans Health Administration, 2009