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FAQ: Will taking PrEP affect my hormone therapy?

for Veterans and the Public

Frequently Asked Questions

Q: I am an HIV-negative transgender woman. Sometimes I'm not sure about the HIV status of my partners and would like to use PrEP to prevent HIV. But, my friends have told me that PrEP will interfere with my hormones. Is this true?

Good news--there is no evidence that the PrEP medicines (tenofovir and emtricitabine) interact with estrogens (or progestins) or affect the levels of hormones in your body. And available data on PrEP in transgender women suggest that it very effectively prevents HIV in trans women who take it every day. Please talk with your VA provider about starting PrEP and about other ways to take care of your health.