for Veterans and the Public
Frequently Asked Questions
Q: I am an HIV-negative transgender woman. Sometimes I'm not sure about the HIV status of my partners and would like to use PrEP to prevent HIV. But, my friends have told me that PrEP will interfere with my hormones. Is this true?
While PrEP does not interfere with the hormones used as part of PHT, there is some evidence that estrogens used in feminizing hormone therapy (FHT) may interact with the tenofovir component in PrEP medicine. Some studies have shown that taking FHT may lower the amount of tenofovir in your body. We do not know for sure if it lowers it enough to make PrEP less effective. Just to be sure, it is best to always use condoms if you are on FHT and taking PrEP and be sure not to miss any doses. Please talk with your VA provider about starting PrEP and about other ways to take care of your health.