Attention A T users. To access the menus on this page please perform the following steps. 1. Please switch auto forms mode to off. 2. Hit enter to expand a main menu option (Health, Benefits, etc). 3. To enter and activate the submenu links, hit the down arrow. You will now be able to tab or arrow up or down through the submenu options to access/activate the submenu links.

HIV/AIDS

Menu
Menu

Quick Links

Veterans Crisis Line Badge
My healthevet badge
EBenefits Badge
 

Drug Dosing Toolkit: Invirase

for Veterans and the Public

saquinavir (Invirase)

Type of Drug: Protease Inhibitor
Once HIV has infected a cell and made copies of itself, it uses an enzyme called protease to process itself correctly so it can be released from the cell to infect other cells. Protease inhibitors work by blocking that enzyme.

Bring a printout of this page to discuss with your doctor during your next visit. List your questions at the bottom of the page.

Approved adult dosing

two 500 mg tablets Invirase + one 100 mg tablet or capsule Norvir two times a day

  • Morning
    Invirase 500Invirase 500

    saquinavir (Invirase) 500 mg tablets

    +
    Norvir 100

    ritonavir (Norvir) 100 mg

  • Evening
    Invirase 500Invirase 500

    saquinavir (Invirase) 500 mg tablets

    +
    Norvir 100

    ritonavir (Norvir) 100 mg

five 200 mg capsules Invirase + one 100 mg tablet or capsule Norvir two times a day

  • Morning
    Invirase 200Invirase 200Invirase 200Invirase 200Invirase 200

    saquinavir (Invirase) 200 mg capsules

    +
    Norvir 100

    ritonavir (Norvir) 100 mg

  • Evening
    Invirase 200Invirase 200Invirase 200Invirase 200Invirase 200

    saquinavir (Invirase) 200 mg capsules

    +
    Norvir 100

    ritonavir (Norvir) 100 mg

Notes on taking this medication

  • Because saquinavir is not as potent or easy to take as some of the newer protease inhibitors, it is no longer recommended for treatment of HIV; if you are taking saquinavir (Invirase), please talk with your clinician about the possibility of changing to a different medication.
  • Take with food or after a meal
  • Saquinavir (Invirase) interacts with many other drugs; persons using saquinavir with those drugs may need an adjustment to their dose of saquinavir or the other drugs; consult your medical provider

Possible side effects

  • Nausea; vomiting; diarrhea; stomach discomfort; headache
  • Liver inflammation and increased liver enzyme levels
  • Elevations in cholesterol and triglycerides
  • Abnormal accumulation of body fat

See accompanying chart: Tips for Common Side Effects

Notes

Disclaimer: This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.