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Drug Dosing Toolkit: Atripla

for Veterans and the Public

Efavirenz + tenofovir DF + emtricitabine (Atripla)

Type of Drug: Fixed-Dose Combination
Fixed-dose combinations combine the most commonly prescribed doses of 2 or more medications into a single pill.

Bring a printout of this page to discuss with your doctor during your next visit. List your questions at the bottom of the page.

Approved adult dosing

Efavirenz (Sustiva) 600 mg + tenofovir DF 300 mg + emtricitabine 200 mg in a single tablet

one tablet Atripla at bedtime

  • Daily


Notes on taking this medication

  • Take at bedtime
  • Take on an empty stomach
  • The efavirenz component interacts with many other drugs; consult your medical provider
  • Persons with kidney problems may need an adjustment to their doses of the component drugs, so may not be able to take this combination pill

Same possible side effects as

Efavirenz (Sustiva)

  • Sleep disturbances such as vivid dreams (improves over the first several weeks); dizziness; drowsiness; mood disturbances, suicidality
  • Difficulty with concentration
  • Rash

Tenofovir DF (Viread)

  • Gassiness; abdominal discomfort; nausea; diarrhea
  • Kidney impairment
  • Bone impairment
  • Tenofovir is active against hepatitis B, and stopping it can cause "flare-up" of hepatitis B

Emtricitabine (Emtriva)

  • Skin discoloration (particularly in dark-skinned people)
  • Emtricitabine is active against hepatitis B, and stopping it can cause "flare-up" of hepatitis B

See accompanying chart: Tips for Common Side Effects


Disclaimer: This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.