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Drug Dosing Toolkit: Aptivus

for Veterans and the Public

Tipranavir (Aptivus)

Type of Drug: Protease Inhibitor
Once HIV has infected a cell and made copies of itself, it uses an enzyme called protease to process itself correctly so it can be released from the cell to infect other cells. Protease inhibitors work by blocking that enzyme.

Bring a printout of this page to discuss with your doctor during your next visit. List your questions at the bottom of the page.

Approved adult dosing

two 250 mg capsules Aptivus + two 100 mg tablets or capsules ritonavir (Norvir) two times a day

  • Morning
    Aptivus 250Aptivus 250

    tipranavir (Aptivus)

    Norvir tabletNorvir tablet

    ritonavir (Norvir)

  • Evening
    Aptivus 250Aptivus 250

    tipranavir (Aptivus)

    Norvir tabletNorvir tablet

    ritonavir (Norvir)

Notes on taking this medication

  • Because of the possibility of severe side effects, Aptivus is not recommended for treatment of HIV; if you are taking Aptivus, please talk with your clinician about the possibility of changing to a different medication
  • Should take with food; a high-fat meal increases absorption
  • Must take with ritonavir (Norvir)

Possible side effects

  • Abdominal pain; nausea; vomiting; diarrhea
  • Rash
  • Elevations in cholesterol and triglycerides
  • Liver inflammation and increased liver enzyme levels

See accompanying chart: Tips for Common Side Effects


Disclaimer: This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.