Table 1. Potential ARV and Other Drug Interactions (BPH)
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- Tamsulosin: Levels may ↑ sharply in patients who are taking P450 inhibitors, including PIs.
- Alfuzosin: Avoid use with patients who are taking P450 inhibitors.
- PIs such as RTV, SQV, IDV, and NFV ↑ serum alfuzosin concentrations.
- Other P450 inhibitors including azole antifungals (eg, ketoconazole, voriconazole, posaconazole, and itraconazole) can ↑ alfuzosin concentrations to toxic volumes. Concurrent use of alfuzosin and azoles can ↑ sthe risk of QTc prolongation.
- Other P450 inhibitors including azole antifungals (eg, ketoconazole, voriconazole, posaconazole, and itraconazole) can ↑ alfuzosin concentrations to toxic levels. Concurrent use of alfuzosin and azoles can increase the risk of QTc prolongation.
- Silodosin: Contraindicated in patients on RTV-boosted PIs or other strong P450 inhibitors.
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From Urology
Primary Care of Veterans with HIV
Office of Clinical Public Health Programs
Veterans Health Administration, 2009
