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Potential ARV and Other Drug Interactions (BPH)

for Health Care Providers

Table 1. Potential ARV and Other Drug Interactions (BPH)

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  • Tamsulosin: Levels may ↑ sharply in patients who are taking P450 inhibitors, including PIs.
  • Alfuzosin: Avoid use with patients who are taking P450 inhibitors.
    • PIs such as RTV, SQV, IDV, and NFV ↑ serum alfuzosin concentrations.
    • Other P450 inhibitors including azole antifungals (eg, ketoconazole, voriconazole, posaconazole, and itraconazole) can ↑ alfuzosin concentrations to toxic volumes. Concurrent use of alfuzosin and azoles can ↑ sthe risk of QTc prolongation.
    • Other P450 inhibitors including azole antifungals (eg, ketoconazole, voriconazole, posaconazole, and itraconazole) can ↑ alfuzosin concentrations to toxic levels. Concurrent use of alfuzosin and azoles can increase the risk of QTc prolongation.
  • Silodosin: Contraindicated in patients on RTV-boosted PIs or other strong P450 inhibitors.

From Urology
Primary Care of Veterans with HIV
Office of Clinical Public Health Programs
Veterans Health Administration, 2009