for Health Care Providers

Updates to the Database of ARV Drug Interactions

HIV Meds Quarterly Research Brief, Summer 2009

Susa Coffey, MD, HIV InSite Medical Editor
Ian R. McNicholl, Pharm.D., BCPS (Added Qualifications-Infectious Diseases), HIV InSite Pharmacy Editor

The following table summarizes recent additions to the HIV InSite Database of Antiretroviral Drug Interactions Link will take you outside the VA website. VA is not responsible for the content of the linked site. . For a full description of the updates, including references to the studies from which the data were derived, click on a specific drug name in the table below and search for the interacting agent.

New ARV Interactions, April-July 2009
Drug One	Drug Two	Clinical Effects	Mechanisms	Management
Source: McNicholl I. HIV InSite Database of Antiretroviral Drug Interactions. University of California San Francisco: Center for HIV Information; 2009
Tenofovir	Etravirine			No dosage adjustment necessary
Nevirapine	Fluconazole	Possibly ↑ nevirapine effects	Inhibition of CYP450 3A4 by fluconazole	No dosage adjustment necessary
Atazanavir	Simvastatin	↑ simvastatin effects (eg, myopathy, rhabdomyolysis)	Inhibition of CYP450 3A4 by atazanavir	Do not coadminister *Alternative agents:* Atorvastatin (low dose); pravastatin

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