for Health Care Providers
Updates to the Database of ARV Drug Interactions
The following table summarizes recent additions to the HIV InSite Database of Antiretroviral Drug Interactions
. For a full description of the updates, including references to the studies from which the data were derived, click on a specific drug name in the table below and search for the interacting agent.
| Drug One | Drug Two | Clinical Effects | Mechanisms | Management |
|---|---|---|---|---|
| Source: McNicholl I. HIV InSite Database of Antiretroviral Drug Interactions. University of California San Francisco: Center for HIV Information; 2009 | ||||
| Raltegravir | Atazanavir | Possibly ↑ raltegravir effects | Dosage adjustment not established | |
| Nevirapine | Fluconazole | Possibly ↑ increased nevirapine effects | Inhibition of CYP450 3A4 by fluconazole | No dosage adjustment necessary |
| Atazanavir | Simvastatin | ↑ simvastatin effects (eg, myopathy, rhabdomyolysis) | Inhibition of CYP450 3A4 by atazanavir | Do not coadminister Alternative agents: Atorvastatin (low dose); pravastatin |
| Efavirenz | Posaconazole | ↓ posaconazole effects | Induction of UDP-G by efavirenz | Avoid coadministration if possible |
| Ritonavir | Posaconazole | ↑ ritonavir effects | Inhibition of CYP450 3A4 by posaconazole | Monitor closely for adverse effects during coadministration |
| Atazanavir | Posaconazole | ↑ atazanavir effects | Inhibition of CYP450 3A4 by posaconazole | Monitor closely for adverse effects during coadministration |
| Atazanavir/ritonavir | Posaconazole | ↑ atazanavir effects | Inhibition of CYP450 3A4 by posaconazole | Monitor closely for adverse effects during coadministration |
| Lopinavir/ritonavir | Prednisone | Possibly ↑ prednisolone effects | No dosage adjustment necessary | |
| Efavirenz | Prednisone | Possibly ↑ prednisolone effects | No dosage adjustment necessary | |
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