for Health Care Providers
New ARV Interactions, January-April 2009
Back to Updates to the Database of ARV Drug Interactions
| Drug One | Drug Two | Clinical Effects | Mechanisms | Management |
|---|---|---|---|---|
Source: McNicholl I. HIV InSite Database of Antiretroviral Drug Interactions . University of California San Francisco: Center for HIV Information; 2009 | ||||
| Raltegravir | Atazanavir | Possibly ↑ raltegravir effects | Dosage adjustment not established | |
| Nevirapine | Fluconazole | Possibly ↑ increased nevirapine effects | Inhibition of CYP450 3A4 by fluconazole | No dosage adjustment necessary |
| Atazanavir | Simvastatin | ↑ simvastatin effects (eg, myopathy, rhabdomyolysis) | Inhibition of CYP450 3A4 by atazanavir | Do not coadminister Alternative agents: Atorvastatin (low dose); pravastatin |
| Efavirenz | Posaconazole | ↓ posaconazole effects | Induction of UDP-G by efavirenz | Avoid coadministration if possible |
| Ritonavir | Posaconazole | ↑ ritonavir effects | Inhibition of CYP450 3A4 by posaconazole | Monitor closely for adverse effects during coadministration |
| Atazanavir | Posaconazole | ↑ atazanavir effects | Inhibition of CYP450 3A4 by posaconazole | Monitor closely for adverse effects during coadministration |
| Atazanavir/ritonavir | Posaconazole | ↑ atazanavir effects | Inhibition of CYP450 3A4 by posaconazole | Monitor closely for adverse effects during coadministration |
| Lopinavir/ritonavir | Prednisone | Possibly ↑ prednisolone effects | No dosage adjustment necessary | |
| Efavirenz | Prednisone | Possibly ↑ prednisolone effects | No dosage adjustment necessary | |
From New ARV Interactions, January-April 2009
HIV Meds Quarterly Research Brief
Spring 2009
