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Drug Dosing Tool: Tivicay (Dolutegravir)

for Veterans and the Public

Tivicay (dolutegravir)

Type of Drug: Integrase Inhibitor
This is the first approved drug in a class of drugs called integrase inhibitors. It works by blocking an enzyme that the virus needs in order to make more virus. The enzyme that it blocks is called HIV integrase.

Note: The recommended dose of Tivicay depends on whether your HIV virus has resistance to other similar drugs, and on what other medications you are taking. It is important to discuss this with your medical provider before you start taking Tivicay or any other medication.

one tablet Tivicay once daily (standard dosage)

  • Daily
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    Tivicay 50 mg

Note: This dosage is recommended for patients who have never taken anti-HIV medications, or who have never taken other integrase inhibitors.

one 50 mg tablet Tivicay two times a day

  • Morning
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    Tivicay 50 mg

  • Evening
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    Tivicay 50 mg

Note: This dose is recommended for patients who have never taken anti-HIV medications, or who have never taken other integrase inhibitors, IF they are also taking a regimen that contains Aptivus, Lexiva, Norvir, or Sustiva; consult your medical provider.

This dose also is recommended for those with certain drug resistance to other integrase inhibitors; consult your medical provider.

Notes on taking this medication

  • Tivicay interacts with certain antacids and laxatives, and with calcium and iron supplements; check with your medical provider before using these. In general, you should take Tivicay 2 hours before or 6 hours after taking these types of medicines and supplements.
  • Tivicay interacts with a tuberculosis medication. If you're being treated for TB or MAC, let your HIV provider know.

Side effects

  • Usually well tolerated; may cause headache or insomnia. In rare cases may cause liver damage, rash, or allergic reaction.
  • Contact your doctor promptly if you experience moderate or severe side effects.

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

Disclaimer: This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.