for Veterans and the Public
- Type of Drug: Protease Inhibitor
- Once HIV has infected a cell and made copies of itself, it uses an enzyme called protease to process itself correctly so it can be released from the cell to infect other cells. Protease inhibitors work by blocking that enzyme.
Bring a printout of this page to discuss with your doctor during your next visit. List your questions at the bottom of the page.
Approved adult dosing
For those who have NEVER taken antiretroviral drugs: one 800 mg tablet Prezista + one 100 mg tablet Norvir or one 150 mg tablet Tybost once a day
Prezista 800 mgor
For those whose HIV virus has darunavir-associated resistance mutations: one 600 mg tablet Prezista + one 100 mg tablet Norvir two times a day
Prezista 600 mg
Prezista 600 mg
Notes on taking this medication
- Must take Prezista with Norvir or Tybost; it is effective only with one of these
- Must take with food
- Prezista interacts with many other drugs; persons using Prezista with those drugs may need an adjustment to their dose of Prezista or the other drugs; consult your medical provider
- Nausea; diarrhea; stomach discomfort
- Liver inflammation and increased liver enzyme levels
- Elevations in cholesterol and triglycerides
- Elevated blood sugar
- Abnormal accumulation of body fat
- Persons who are allergic to sulfa drugs may be allergic to Prezista
See accompanying chart: Tips for Common Side Effects
Disclaimer: This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.