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Drug Dosing Toolkit: Prezista

for Veterans and the Public

Prezista (darunavir, TMC-114)

Type of Drug: Protease Inhibitor
Once HIV has infected a cell and made copies of itself, it uses an enzyme called protease to process itself correctly so it can be released from the cell to infect other cells. Protease inhibitors work by blocking that enzyme.

Approved adult dosing

For those who have NEVER taken antiretroviral drugs: one 800 mg tablet Prezista + one 100 mg tablet or capsule Norvir, once a day

  • Daily
    image of a 800 mg Prezista pill

    Prezista 800 mg

    Norvir tablet


For those whose HIV virus has darunavir-associated resistance mutations: one 600 mg tablet Prezista + one 100 mg tablet or capsule Norvir, two times a day

  • Morning
    Prezista 600

    Prezista 600 mg

    Norvir tablet


  • Evening
    Prezista 600

    Prezista 600 mg

    Norvir tablet


Notes on taking this medication

  • Must take Prezista with Norvir; it is effective only with the use of Norvir
  • Must take with food
  • Prezista interacts with many other drugs; persons using Prezista with those drugs may need an adjustment to their dose of Prezista or the other drugs; consult your medical provider

Side effects

  • Nausea; diarrhea; stomach discomfort
  • Rash
  • Liver inflammation and increased liver enzyme levels
  • Elevations in cholesterol and triglycerides
  • Elevated blood sugar
  • Abnormal accumulation of body fat
  • Persons who are allergic to sulfa drugs may be allergic to Prezista

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

Disclaimer: This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.