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Drug Dosing Toolkit: Lexiva

for Veterans and the Public

Lexiva (fosamprenavir)

Type of Drug: Protease Inhibitor
Once HIV has infected a cell and made copies of itself, it uses an enzyme called protease to process itself correctly so it can be released from the cell to infect other cells. Protease inhibitors work by blocking that enzyme.

Approved adult dosing

two 700 mg tablets Lexiva two times a day

  • Morning
    Lexiva 700Lexiva 700

    Lexiva

  • Evening
    Lexiva 700Lexiva 700

    Lexiva

Note: This dosage may not be appropriate for people who have taken other HIV medications in the past; discuss with your medical provider.

one 700 mg tablet Lexiva + one 100 mg tablet or capsule Norvir, two times a day

  • Morning
    Lexiva 700

    Lexiva

    +
    Norvir 100

    Norvir

  • Evening
    Lexiva 700

    Lexiva

    +
    Norvir 100

    Norvir

two 700 mg tablets Lexiva + two 100 mg tablets or capsules Norvir, once a day

  • Daily
    Lexiva 700Lexiva 700

    Lexiva

    +
    Norvir 100Norvir 100

    Norvir

Note: This dosage may not be appropriate for people who have taken other HIV medications in the past; discuss with your medical provider.

two 700 mg tablets Lexiva + one 100 mg tablet or capsule Norvir, once a day

  • Daily
    Lexiva 700Lexiva 700

    Lexiva

    +
    Norvir 100

    Norvir

Note: This dosage may not be appropriate for people who have taken other HIV medications in the past; discuss with your medical provider.

Notes on taking this medication

  • No food restrictions, can take with or without food
  • Lexiva interacts with many other drugs; persons using Lexiva with those drugs may need an adjustment to their dose of Lexiva or the other drugs; consult your medical provider

Side effects

  • Nausea; vomiting; diarrhea; fatigue; headache
  • Rash
  • Persons who are allergic to sulfa drugs may be allergic to Lexiva
  • Liver inflammation and increased liver enzyme levels
  • Elevations in cholesterol and triglycerides
  • Abnormal accumulation of body fat

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

Disclaimer: This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.