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Drug Dosing Toolkit: Crixivan

for Veterans and the Public

Crixivan (indinavir)

Type of Drug: Protease Inhibitor
Once HIV has infected a cell and made copies of itself, it uses an enzyme called protease to process itself correctly so it can be released from the cell to infect other cells. Protease inhibitors work by blocking that enzyme.

Approved adult dosing

two 400 mg capsules Crixivan + one 100 mg capsule or tablet Norvir, two times a day

  • Morning
    Crixivan 400mgCrixivan 400mg

    Crixivan

    +
    Norvir 100mg

    Norvir

  • Evening
    Crixivan 400mgCrixivan 400mg

    Crixivan

    +
    Norvir 100mg

    Norvir

two 400 mg capsules Crixivan + two 100 mg capsules or tablets Norvir, two times a day

  • Morning
    Crixivan 400mgCrixivan 400mg

    Crixivan

    +
    Norvir 100mgNorvir 100mg

    Norvir

  • Evening
    Crixivan 400mgCrixivan 400mg

    Crixivan

    +
    Norvir 100mgNorvir 100mg

    Norvir

two 400 mg capsules Crixivan every 8 hours

  • 6AM
    Crixivan 400mgCrixivan 400mg

    Crixivan

  • 2PM
    Crixivan 400mgCrixivan 400mg

    Crixivan

  • 10PM
    Crixivan 400mgCrixivan 400mg

    Crixivan

Notes on taking this medication

  • Take on an empty stomach 2 hours after or 1 hour before meal
  • When boosted with Norvir, Crixivan can be taken with food
  • Drink 6-8 glasses of water per day to reduce risk of kidney stones
  • Crixivan interacts with many other drugs; persons using Crixivan with those drugs may need an adjustment to their dose of Crixivan or the other drugs; consult your medical provider

Side effects

  • Kidney stones; flank or back pain
  • Nausea; vomiting; diarrhea; headache
  • Abnormal accumulation of body fat
  • Increased blood sugar
  • Elevations in cholesterol and triglycerides
  • Liver inflammation and increased liver enzyme levels
  • Hair loss; dry skin; ingrown nails
  • Jaundice (yellowing of the eyes or skin)

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

Disclaimer: This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.