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Drug Dosing Toolkit: Aptivus

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for Veterans and the Public

Aptivus (tipranavir)

Type of Drug: Protease Inhibitor
Once HIV has infected a cell and made copies of itself, it uses an enzyme called protease to process itself correctly so it can be released from the cell to infect other cells. Protease inhibitors work by blocking that enzyme.

Approved adult dosing

two 250 mg capsules Aptivus + two 100 mg capsules or tablets Norvir, two times a day

  • Morning

    Aptivus 250Aptivus 250

    Aptivus

    +
    Norvir tabletNorvir tablet

    Norvir

  • Evening

    Aptivus 250Aptivus 250

    Aptivus

    +
    Norvir tabletNorvir tablet

    Norvir

Notes on taking this medication

  • Should take with food; high-fat meal increases absorption
  • Must take with Norvir
  • Aptivus interacts with many other drugs; persons using Aptivus with those drugs may need an adjustment to their dose of Aptivus or the other drugs; consult your medical provider

Side effects

  • Abdominal pain; nausea; vomiting; diarrhea
  • Rash
  • Elevations in cholesterol and triglycerides
  • Liver inflammation and increased liver enzyme levels

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

Disclaimer: This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.

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